Monoclonal antibodies might kill COVID-19, replace plasma therapy

Researchers around the world are trying to figure out all possible ways to fight off the pandemic. Numerous vaccine candidates and drugs are already on trial to see the effectiveness against COVID-19. However, the answer might be with the help of this possible therapy – the use of monoclonal antibodies is showing promising results against the disease.

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Two independent teams from the Netherlands and Japan have developed potential monoclonal antibodies against the virus, and such antibodies have neutralized the virus in laboratory conditions. Soon, we can expect this therapy out for human trials to prove its reliability, but this is not the first time such antibodies are in use. We already saw plasma therapy using antibodies is helping affected patients worldwide. This has led to saving a number of patients from critical danger around the world. But the drawback is that this therapy cannot meet the demands on a large scale. Therefore, scientists say this alternative therapy can easily replace the conventional plasma ones in saving lives.

The Monoclonal Antibody: 47D11

The monoclonal antibody going by the name 47D11 is developed by the Dutch team is obtained from genetically modified mice infected with the disease. These antibodies directly target the spike portions in the virus, which facilitate entry and replication. Therefore, inhibiting the spike will stop the virus from spreading inside the body. Moreover, the antibodies also inhibit SARS-CoV, which are also from the same clade. Therefore, further humans trials will open boundaries about the effectiveness of this treatment.

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Researchers from Japan have also come up with a new antibody candidate called the VHH. This component is said to serve from camelids who transmitted the MERS back in 2014. VHH is potentially easy to create because it is derived from microorganisms rather than a laboratory animal. While comparing other methods, this seems to be cost-effective with additional benefits. Although these antibodies suppress the disease, it is still unclear how long it is effective. Therefore further studies with additional clinical trials will help figure out the questions.

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Source: BGR

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