The new trend of reducing heart-related complications is unique, and it will attract young people very sooner. A new study claims to increase the fat-rich diet to reduce the heart failure condition caused by a metabolic process. Although it sounds interesting, we should see it as a red flag.
Researchers from Saint Louis University have done works on heart failure mice and found a link to favor fat diet in terms of heart problems. They identified that the myocardium is flexible, and so it requires a lot of chemical energy for effective functioning, which is provided by nutrients. As energy demand is more in the case of the heart, it can easily adapt to the different metabolic diets.
The study said about the presence of mitochondrial pyruvate carrier (MPC1 & MPC2), which is in need necessary for the transport of pyruvate into mitochondria. Cardiac mitochondria are capable of oxidizing fatty acids, pyruvate, ketone bodies, or even amino acids. Fatty acids are a major fuel source for normal adult hearts. During heart failure, the fatty acid oxidation system is impaired, and so it has to rely on pyruvate, which transports through MPC. However, these MPC1 and MPC2 reduced significantly in mouse and human heart complications. It further proceeds to cardiac dilation, ending up in contractile dysfunction. More precisely, we can say that the MPC gene deletion causes cardiac remodeling and dysfunction.
Nonetheless, when they keep the mice starved, it would lead to ketogenesis, which might improve the remodeling process. Also, other than ketogenic food, we can provide foods high in fat but with enough carbs to limit ketosis. Therefore, takings high fat and lower carbohydrate diets might be one of the potential ways nutritionally to treat heart failure.
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Source: Medical Xpress