Lyme disease, a most common vector-borne disease, caused by the bacterium Borrelia burgdoferi. It transmits to humans through the bite of infected black-legged ticks. However, the typical symptoms include fever, headache, fatigue, and a characteristic skin rash (erythema migrans). Nevertheless, it spreads to the heart, nervous system, and also joints causing havoc to the individual.
Researchers from Yale University discovered a protein that confers immunity against the spirochete. The protein named Peptidoglycan Recognition Protein 1( PGLYRP1) acts as an initial signal to the immune system. To come to this conclusion, they have analyzed more than 10000 human genes and their synergistic actions with 36 samples of B.burgdorferi. They identified that one protein was really effective at the initial stages. When they researched mice, that lacks PGLYRP1, they found that the bacterial load was much higher, and also the immune system of mice had impaired.
Eventually, the study reported stimulating the protein level inside the body to tackle the infection. Also, an enhanced range of this specific protein might reduce the susceptibility of the person to Lyme. Further research will make us proceed in the right direction.
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Source: Medical Xpress