BICRA gene is responsible for undiagnosed neurodevelopmental disorders, scientists find

We know there are quite a lot of idiopathic cases in the medical and veterinary profession. Scientists are on a search to look after genes, which could provide valuable insight into certain cases. Recently, experts from the Baylor College of Medicine and also other institutions found a gene BICRA that causes neurodevelopmental defects. The study published in the American Journal of Human Genetics along with evidential proof.

The researchers explored a controversial case, which is distinct from the Coffin-Siris syndrome. The patient suffers from several neurological defects, and the genetic assay reveals a mutation in the BICRA gene. For instance, they found 11 more patients with similar mutations in the gene by using the software GeneMatcher.

Moreover, the mutation observed in 12 patients were all acquired, and this means there is no inheritance of the mutagenic genes. The gene loses its function after undergoing mutation (dominant), thereby ending up in neural disorder.

To come to an appropriate conclusion, the scientist tested the function of the BICRA gene in zebrafish and fruit flies. They induced a mutation in the zebrafish, and possibly mimics the sequence as inpatients. As a result, the zebrafish developed craniofacial defect as same as one of the patients experienced. Similarly, in fruit flies, they identified that the gene was expressed in the nuclei of the neuron and glial cells. By discovering those genes earlier, we could establish the possible outcome by certain gene therapies or targeted medicines.

Do you want to publish on Apple News, Google News, and more? Join our writing community, improve your writing skills, and be read by hundreds of thousands around the world!

Source: Medical Xpress

More from Health – News Landed

+ Radical testing of COVID-19 patients could solve the epidemic in weeks, new study says
+ Unraveling the molecular mechanism for Alzheimer’s disease

+ Netflix India faces backlash over ‘A Suitable Boy’ temple kiss scene
+ Francisco Sagasti: Peru’s newest interim President

Related Stories

Gene therapy to restore vision in mice

Blindness is a global problem where a person cannot see anything, including light. Researchers find novel ways like gene...

Egypt: 59 archaeological coffins announced in the Saqqara region

In a media conference, Egypt announced the discovery of 59 archaeological coffins in the Saqqara area in Giza, in...

Featured Stories

Will Telosa be the “City of the Future” by 2030?

Shenzhen, China was a sleepy fishing village in 1979. A mere forty years later, it is one of the...

Low-cost lead adsorbing water filter designed by Indian students

Two students from India have designed a low-cost lead water filter that can be made with locally sourced materials....

Make it Rain! Dubai uses drones to conjure rain from the skies

You can order food, hail a driver, and even find a spouse with the click of a button; but...

Physicists have created the world’s thinnest magnet. Just one atom thick!

Can you guess the size of the thinnest magnet? It is just one atom thick. Scientists from the University of...

Boris Johnson and Rishi Sunak reverse decision to avoid self-isolation following ping by NHS contact tracing

Following the Health Secretary's diagnosis with COVID-19, the Prime Minister and Chancellor were notified by NHS Test and Trace...

India is one of the largest producers of COVID vaccine and yet faces major internal shortages

The worsening situation in India finally gained some stabilization around September 2020. Usually, when things start getting better, people...