Inflammasome activation by fungus gets attraction among researchers

Scientists discovered a pathway by which the Aspergillus fungi stimulates the body’s innate immune system. For instance, there were many questions regarding inflammasome activation, which was the sentinel of the immune system. So far, we know that the fungi activate the inflammasomes, but the mechanism of how it activates remains debatable.

Inflammasome and fungi

Inflammasomes are cytosolic multiprotein oligomers of the innate immune system responsible for the activation of inflammatory responses. Also, activation of this structure promotes proteolytic cleavage and also secretes other cytokines needed for inflammation.

- Advertisement -

The researchers analyzed the pathogen-associated molecular pattern, which can potentiate the inflammatory cytokines. Notably, they identified a compound galactosaminogalactan (GAG) in Aspergillus fumigatus, that could over-activate the inflammatory sensor NLRP-3. This protein further activates the inflammasome reaction within the cell.

Read Also: A cost-effective tool to select the best microalgae for biodiesel production

Therefore, GAG present in the fungi plays an important role in activating the inflammasome. Fungi that lack GAG doesn’t seem to stimulate the inflammatory response. Inflammasome activation is one of the important steps inside the body to get rid off of the pathogen. And so, it is protective in nature.

Scientists also showed that fungi without GAG were more virulent in mice than the fungi which mediate via inflammasomes. In conclusion, this study might indicate to develop purified GAG to promote immunity, and thus helps to prevent infections.

- Advertisement -

Do you want to publish on Apple News, Google News, and more? Join our writing community, improve your writing skills, and be read by hundreds of thousands around the world!

Source: Medical Xpress

More from Science – News Landed

+ Escaped Danish mink from fur farms has the potential to infect wild animals with SARS-CoV-2
+ Jupiter and Saturn will appear as a double planet on the winter solstice

+ Spaceflight can disrupt Mitochondrial activity leading to health issues
+ Jupiter and Saturn will appear as a double planet on the winter solstice

Related Stories

India approves COVID-19 vaccine

India approved two vaccines for the coronavirus earlier this week, COVISHIELD developed by the Serum Institute of India, the...

Groundbreaking previously unknown population of Whales are found in the Indian Ocean

In a new study published in the Endangered Species Research, it was found a new population of Whale whose...

Featured Stories

Sturgill Simpson Stops Struggling

Sturgill Simpson has always seemed to struggle. He would prefer being listened to as opposed to just being heard....

Climate change ultimately caused the demise of Transoxania

Climate change doomed the ancient Transoxania civilization, suggests a new study.  An international team of scientists analyzed sediment samples from...

Arecibo Observatory in Puerto Rico collapses

The Arecibo Observatory in Puerto Rico witnessed the crash of its pathbreaking telescope on late Tuesday morning. One of...

Next Step: Jurassic Park? Scientists digitally reconstruct dinosaur brain

As the blockbuster Jurassic Park/World franchise taught us--despite being extinct for more than 60 million years--"Life finds a way", and there...

A tsunami-like mechanism in mice brains teach us more about migraines

A migraine with aura is a severe headache that accompanies symptoms like dizziness, zigzag line vision, blind spots, tingling...

Joseph R. Biden and Kamala D. Harris elected to the White House

At around 11:25 a.m. on November 7, 2020, after nearly 90 hours since polls first closed throughout the United...

Comment Below

India approves COVID-19 vaccine

India approved two vaccines for the coronavirus earlier this week, COVISHIELD developed by the Serum Institute of India, the...

Groundbreaking previously unknown population of Whales are found in the Indian Ocean

In a new study published in the Endangered Species Research, it was found a new population of Whale whose...