Ancient antibiotics to prevent the opioid epidemic in future

The majority of people suffer from chronic pain, which is perhaps due to various disease conditions like cancer, diabetes, or trauma. In general, more than 100 million Americans are undergoing different opioid therapies for neuropathic pain. For instance, people had taken the potential painkillers since the 1990s. The hapless situation created now was drug abuse and overdosage. So, the scientists are in search of the best alternatives to relieve the pain thus minimizing the abusive opioid painkillers.

Researchers identified a protein EphB1 that is present on the surface of the nerve cells. This protein acts as a key link in developing neuropathic pain. They did work on mice after genetically removing EphB1 protein. To a surprise, the mice did not feel any pain after removing the protein. This has hinted them to experiment with therapeutic agents to target EphB1 protein. They started analyzing the molecular structure of the protein and corresponding it to the specific agent. Three longtime antibiotics like demeclocycline, chlortetracycline, minocycline have the potential to bind to this protein and can subsequently reverse the pain. The experts have done it in Petri dishes to prove the success of the treatment. Besides, looking further to crystallography gave similar outcomes just like the previous one.

A combination of these three drugs, when given to different mouse models of neuropathic pain has sufficiently reduced painful stimuli like heat or pressure than giving one drug alone. While performing postmortem, the physicians got the sample of the brain and spinal cord to check the activity of EphB1 protein. The result showed that the protein was inactivated and made the researchers hit the jackpot. This kind of alternative treatment could probably prevent the opioid epidemic shortly.

Do you want to publish on Apple News, Google News, and more? Join our writing community, improve your writing skills, and be read by hundreds of thousands around the world!

Source: Medical Xpress

More from Health – News Landed

+ Platelet may be the culprit for causing lupus, experts say
+ People unlikely to suffer from thrombocytopenia after receiving COVID-19 vaccine

+ A map of Black Holes in the Northern sky
+ Disney+ crashes after users rush to watch the latest ‘WandaVision’ episode

Related Stories

Boris Johnson and Rishi Sunak reverse decision to avoid self-isolation following ping by NHS contact tracing

Following the Health Secretary's diagnosis with COVID-19, the Prime Minister and Chancellor were notified by NHS Test and Trace...

Singapore Road map to become New normal

The deadly coronavirus may never go away but it is possible to live normally with it in our midst....

Featured Stories

Will Telosa be the “City of the Future” by 2030?

Shenzhen, China was a sleepy fishing village in 1979. A mere forty years later, it is one of the...

Low-cost lead adsorbing water filter designed by Indian students

Two students from India have designed a low-cost lead water filter that can be made with locally sourced materials....

Make it Rain! Dubai uses drones to conjure rain from the skies

You can order food, hail a driver, and even find a spouse with the click of a button; but...

Physicists have created the world’s thinnest magnet. Just one atom thick!

Can you guess the size of the thinnest magnet? It is just one atom thick. Scientists from the University of...

Boris Johnson and Rishi Sunak reverse decision to avoid self-isolation following ping by NHS contact tracing

Following the Health Secretary's diagnosis with COVID-19, the Prime Minister and Chancellor were notified by NHS Test and Trace...

India is one of the largest producers of COVID vaccine and yet faces major internal shortages

The worsening situation in India finally gained some stabilization around September 2020. Usually, when things start getting better, people...