The reason behind harmful glial cell change in motor neuron disease remains clear, study says

Amyotrophic lateral sclerosis (ALS) is a group of rare neurological diseases that mainly involve the neurons responsible for controlling voluntary muscle movement. The disease is perhaps progressive, and there is no cure or effective treatments. Early symptoms include muscle stiffness and the patients generally die of respiratory failure within 3 years.

When the researchers looked deep into the molecular physiology, they noticed a cellular change for causing ALS. As the nervous system damages, the star-shaped cell named astrocytes, behave strangely by undergoing a reactive change. Although some of this change is protective in nature, others become evil and damage the surrounding neurons. The reason for what causes the change in astrocytes still remains unknown.

Read Also: Turning off the GLI1 gene may help us in treating several cancers

To get a result, scientists used human induced pluripotent stem cells to compare with diseased individuals. Both normal and unusual astrocytes are compared to find out the root cause of change. Interestingly, they found that the reason for the change in the astrocytes was due to the removal of introns. These are non-coding sections of the genetic information. Altogether, the process is called splicing. In a healthy individual, the RNA pulls back introns and so there is not much splicing. Besides, when the introns are removed, the coding section sweeps around to develop proteins, which may result in the change of astrocytes.

A previous study has declared that splicing is reduced in ALS motor neurons, but in ALS astrocytes, it has increased resulting in only exons. This puzzling conclusion demanded upcoming clarification on it. This might be due to toxic immune insult to the immune cells when they got activated. Further research would make us clear and might help us in developing treatments for neurological disease conditions.

Do you want to publish on Apple News, Google News, and more? Join our writing community, improve your writing skills, and be read by hundreds of thousands around the world!

Source: Medical Xpress

More from the Science – News Landed

+ A slowing Gulf Stream System would put the eastern US and western Europe at risk
+ Another variant of the COVID-19 virus emerge in Washington

+ Pope Francis moves at full speed toward Saturday’s visit with Grand Ayatollah Ali al-Sistani
+ Dale Steyn apologizes after his words on IPL create a controversy

Related Stories

India’s approval to Sputnik V amid the rising concern of vaccine shortage

The second wave of COVID-19 is wreaking havoc in India as it recorded over 1.61 lakh fresh Covid-19 cases...

mRNA may play a crucial role for treating brain disorders

Cerebral ischemia, a condition resulting from impaired blood flow to the brain, is one of the leading causes of...

Featured Stories

North Korea’s nuclear test sparks conflict

The United States of America, Japan, and South Korea have collaborated to pressurize "North Korea's nuclear and ballistic missiles...

The molecular underpinning of stem cells to form the kidney seeks attention by the scientists

The mammalian kidney is a distinctive organ, that evolves on basis of an interplay between epithelial and mesenchymal tissues....

Nike blocks all sales and gets a restraining order against rapper Lil Nas X’s ‘Satan Shoes’

Nike has quite literally fought against the devil, trying to get the 'Satan Shoes' to be stopped from being...

Discovery of a new type of black hole bridges the gap between Stellar and Supermassive black holes

A black hole is a region in space where gravity is so strong that no particles, including electromagnetic radiation,...

Goldilock protein which sets for proper immune response remains known, researchers say

There are certainly a lot of abnormal actions produced by the immune cells. It can be of any autoimmune...

A golden mask discovered in China dating back 3 thousand years

A number of Chinese archaeologists have been able to find an archaeological discovery described as historical, while they are...